Skip to content
60-day money-back guaranteeFrom $49 a bottle on 6 bottlesFree US shipping on 3 and 6 bottles

L-Arginine and L-Citrulline: Nitric Oxide Explained

By the Mind Honey Editorial Team. Updated September 2026. Checked against the published Supplement Facts panel.

Quick answer: Arginine and citrulline are amino acids the body uses to make nitric oxide, which relaxes blood vessels. Studies used grams a day; Mind Honey Pro provides 400 mg and 200 mg.

The nitric oxide cycle

Blood-vessel cells use the enzyme nitric oxide synthase to turn arginine into nitric oxide and citrulline. Nitric oxide relaxes the vessel wall. The kidneys can recycle citrulline back into arginine.

Why pair them?

A lot of swallowed arginine is broken down in the gut and liver before it reaches the blood. Citrulline avoids much of that and raises blood arginine more reliably.

What the research used

Blood pressure and exercise studies used roughly 3 to 9 g of arginine or 3 to 8 g of citrulline a day. PubMed: citrulline and blood pressure.

Safety

Because they lower blood pressure, they need care with nitrates, ED drugs and blood pressure medicine; see the interaction guide.

General information, not medical advice. Mind Honey Pro is a dietary supplement and is not intended to diagnose, treat, cure or prevent any disease.

From $49 a bottle, 60-day guaranteeCheck price